BDBM8909 6-(pyridin-3-yl)naphthalene-2-carbonitrile::6-Pyridin-3-yl-2-naphthonitrile::CHEMBL196796::Pyridine-substituted naphthalene 8::US9271963, 8

SMILES N#Cc1ccc2cc(ccc2c1)-c1cccnc1

InChI Key InChIKey=BRNSTMOAGOETDI-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8909   

TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
Affinity DataIC50:  691nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
Affinity DataIC50:  691nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZh cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8909(6-(pyridin-3-yl)naphthalene-2-carbonitrile | 6-Pyr...)
Affinity DataIC50:  691nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In DepthDetails US Patent